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CHIR99021 potentiates self-renewal of human and mouse embryonic stem cells and enhances reprogramming of somatic cells into stem cells. CHIR99021 also augments the differentiation potential of mesenchymal stem cells.
CHIR99021 is a highly potent and -selective inhibitor of GSK3α (IC50 of 10) and GSK3β (IC50 of 6.7), exhibiting over 500-fold selectivity when compared to its nearest homologs. CHIR99021 has been an effective component within differentiation protocols of pluripotent stem cells (PSCs) into human pancreatic beta cells (Pagliuca, et al.), neural progenitor cells (Li, et al. & Qi, et al.), cardiovascular progenitor cells (Cao, et al.), and functional cardiomyocytes (Lian, et al. & Burridge, et al.).
Additionally, CHIR99021 has been shown to promote the induction of human PSCs (Li, W. et al.) and self-renewal of PSCS for maintenance purposes (Ying, et al.). CHIR99021 has also been shown to augment the differentiation potential of mesenchymal stem cells (Govarthanan et al.).
Description: Highly selective GSK-3 inhibitor; acts as Wnt activator Alternative Names: CHIR99021, CT99021 Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Purity: ≥ 98%
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